The National Institute on Aging (NIA), National Institutes of Health (NIH), invites Exploratory/Developmental Research Grant (R21) applications from institutions/organizations that propose to develop tools to track cell fate determination (cell lineage) and to determine cell life spans in normal tissue homeostasis and in response to injury or disease in the elderly. This Funding Opportunity Announcement (FOA) will support basic and applied exploratory/developmental research projects for the development of tools needed to determine cell life spans and cell fates in various tissues of aged mammals, specifically in humans or in model organisms (e.g., rodents or nonhuman primates). Applications will address the design, development and quantitative testing of integrated systems for cell turnover rates and lineage tracing in one or more cell types. Such systems should be applicable to determine the age-dependent changes in cellular turnover and fates in tissues that lose function with advanced age. Application and submission requirements, and peer review processes will follow NIH guidelines (outlined in this FOA).

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