This FOA, The Microbicide Innovation Program (MIP IV), issued by NIAID, NIMH, and supported by the Office of Research in Women’s Health (ORWH) in the Office of the Director, National Institutes of Health, solicits Research Project Grant (R21/R33) applications in the field of topical microbicides to advance:

• Development of new microbicide approaches and additional rational targets through preclinical and basic research;
• Discovery and characterization of microbicides (singly or in combinations) directed against HIV or STIs (Sexually Transmitted Infections) that are linked to HIV acquisition;
• Emerging technologies or models that contribute to the development of new and/or more efficient ways of assessing microbicide safety, efficacy and acceptability; and,
• Design of complex prevention strategies that incorporate vaginal, rectal, and/or penile applied microbicides in the context of mucosally active vaccines.

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