The National Institute of Allergy and Infectious Diseases (NIAID) and the National Institute on Aging (NIA), National Institutes of Health, invite Research Project Grant (R01) applications from institutions/organizations that propose to study the biology of thymic involution and the decline of naïve T cell production, differentiation, and function in the aged population (defined as individuals over 50 years of age, for the purpose of this FOA). This Funding Opportunity Announcement (FOA) will support basic and applied research projects that utilize appropriate animal models and/or in vitro human cells/tissues to understand the mechanisms responsible for thymic involution and decreased naïve T cell production and function, or to analyze the functional activity of the T cells, beneficial or detrimental, generated from experimental or clinical approaches to reverse or prevent thymic involution and increase naïve T cell output in patients exhibiting immune senescence.      

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