The objective of this Funding Opportunity Announcement (FOA) is to stimulate research on tumor stem cell biology, including the identification and characterization of specific genetic and functional signatures (e.g., biomarkers) of tumor stem cells. The overall goal is the translation of basic research findings into clinical practice in the contexts of both hematological and solid tumor malignancies. Applications submitted in response to this RFA must propose interdisciplinary Program Projects that comprehensively address novel aspects of the biology of tumor stem cells (tumor initiating cells) combined with the meaningful translation of basic research findings into a clinically-relevant context. Each application must propose at least three individual (albeit connected) research projects pertinent to a single unifying research theme. At least one of these projects must address basic aspects of tumor cell biology and at least one project must center on translation of such basic research findings into a clinically-relevant context. The other projects may focus on either basic or translational research or combine both aspects. It is expected that the proposed Program Projects will involve substantive collaborative arrangements between basic and translational researchers. Therefore, applicants are encouraged to consider the Multiple Principal Investigators option.

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